What is the most appropriate route for naloxone administration?…

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Cloie Jomariz P. Cudiamat · Accepted Answer

Correct Answer: Intranasal Reasoning: Intranasal (IN): This is a standard, FDA-approved, and widely used route for naloxone administration (e.g., Narcan nasal spray), especially in community and first-responder settings. It is safe, effective, and needle-free. Rectal: While technically possible in extreme "off-label" situations where no other route is available, it is not considered a standard or "most appropriate" route for naloxone compared to Intranasal, Intramuscular, or Intravenous. Sublingual: Naloxone has very poor bioavailability when taken sublingually (under the tongue). It is often combined with buprenorphine in sublingual films (like Suboxone), but in that context, the naloxone is there to be inactive (unless injected) to prevent abuse. It is not an effective route for reversing an overdose. Intradermal: This route (injecting into the skin layers) is typically used for diagnostic tests (like TB tests) and is not appropriate for administering emergency medication like naloxone. Although the prompt says "Select all that apply," Intranasal is the only standard and appropriate route listed here.

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Cloie Jomariz P. Cudiamat

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